(FREE) Simplified Harvest and Media Exchange in Cell Therapy: Consistent, Compliant Scale-Up from Development to GMP

Developing robust cell harvest and media exchange processes is often complex, particularly when moving from development to GMP manufacturing. Differences in equipment, scale, and automation can introduce variability and delay clinical timelines. Common methods such as TFF face challenges in maintaining consistent parameters during scale-up, while disc-stack centrifugation lacks scale-down models and can expose cells to high shear, reducing viability and product quality. Manual approaches, though gentler, increase variability and labor demands as processes scale. These issues complicate tech transfer, process validation, and regulatory alignment.

This webinar presents case studies demonstrating how a low-shear, single-use centrifuge supports efficient harvest and media exchange for diverse cell types, including iPSC aggregates and MSCs, while preserving critical quality attributes (CQAs). The approach enables consistent process parameters and predictable performance from development through commercial manufacturing. By reducing engineering complexity and simplifying scale-up, this technology helps shorten time-to-clinic.