Enabling the full potential of process chromatography

Successfully scaling a purification process from development to GMP manufacturing requires maintaining process performance while minimizing variability. However, scale-up often introduces challenges that can impact productivity, recovery, and overall process efficiency. To mitigate risk, manufacturers frequently apply conservative safety factors during scale-up—resulting in lower resin utilization, increased buffer consumption, longer process times, and reduced overall productivity.

What if you could maintain the same critical process parameters (CPPs) and critical quality attributes (CQAs) from bench scale through commercial manufacturing with greater confidence and control?

Join Repligen for an in-depth discussion on how advanced process control and real-time analytics can help close the gap between process development and manufacturing performance.

This webinar will explore key considerations for implementing real-time monitoring and control strategies in chromatography processes. Industry experts will discuss the capabilities of the KRM® chromatography platform and the integration of FlowVPX® Process Analytical Technology (PAT) for in-line product concentration measurement.

Attendees will learn how these technologies can be applied to support process characterization, monitor purification performance, and generate data that may inform scale-up and manufacturing decisions while maintaining focus on critical quality attributes.

What You’ll Learn:

Why purification processes often lose efficiency during scale-up
How improved process accuracy and precision can increase yield and productivity
Best practices for maintaining CPPs and CQAs from development through GMP manufacturing
How the KRM® platform supports advanced chromatography process control
How integrated FlowVPX® PAT enables real-time concentration monitoring and process optimization
Strategies to improve resin utilization, reduce buffer consumption, and maximize recovery

Who Should Attend?

Process Development Scientists
Downstream Process Engineers
Manufacturing Scientists
MSAT Professionals
Biologics and Cell & Gene Therapy Professionals
Purification and Chromatography Specialists

Register Today

Discover how real-time process analytics and intelligent chromatography control can help you achieve higher yields, greater process consistency, improved resin utilization, and increased manufacturing productivity—without compromising product quality.