Next-Generation Degraders & Glues
Designing and Optimizing PROTACs, Molecular Glues and Other Degrader Modalities The ubiquitin-proteasome, lysosome and autophagy systems are all well-controlled, selective degradation pathways that are key cellular regulators in cancer, CNS and other diseases. A new generation of hetero bi-functional chimeras and small molecule monovalent degraders are being developed to hijack these systems for targeted protein...